A recent study1 confirmed the ability of Omya International’s Omyapharm platform to formulate orally disintegrating tablets (ODTs) with enhanced mouth feel. The multifunctional excipient from Omya is a highly structured mineral based on calcium carbonate and calcium phosphate.
The study found that the tablets were well accepted by volunteers and—in correlation with an in vitro model—disintegrated fast in vivo. Additionally, the compactibility and the physical stability of the tablets were preserved, delivering the high porosity required to absorb the liquid necessary for disintegration.
The findings lead to the conclusion that Omyapharm is a suitable excipient for ODT dosage forms with a pleasant mouth feel, according to the company.
The main challenge in ODT development is simultaneously to ensure fast disintegration time, physical stability, taste masking, acceptable mouth feel, as well as a cost-effective production process. Omya reported that the study demonstrated that Omyapharm as an excipient can be successfully formulated into ODTs without any unpleasant sensation in the mouth.
Omyapharm 500-OG can be effectively formulated into tablets via dry granulation (roller compaction). Because of their high mechanical strength, the resulting tablets can be filled in conventional packaging, thus reducing costs and potential difficulties during the conditioning process.
Along with fast disintegrating formulations such as orally dispersible tablets and granules, the mineral excipient also is suitable for use in conventional tablets and capsules, the company said.
Omya International AG, founded in 1884 in Switzerland, is a global producer of calcium carbonates and a worldwide distributor of specialty additives and premium services.
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Reference:
1 Wagner-Hattler L, Wyss K, Schoelkopf J, Huwyler J, Puchkov M: In vitro characterization and mouth feel study of functionalized calcium carbonate in orally disintegrating tablets. Int J Pharm. 2017 Dec 20;534(1-2):50-59.
(Source: Omya International AG)
