NEW YORK (AP) — Pfizer and the Justice Department say the drugmaker will pay almost $491 million to resolve an investigation into illegal marketing of the company’s organ transplant drug Rapamune.

Rapamune was approved in 1999 for use in kidney transplant patients, and the Justice Department says sales representatives were trained to market the drug for use in other patients.

The U.S. Department of Justice says Pfizer Inc. will pay $257.4 million in civil settlements with federal and state governments and a $157.6 million criminal fine. It will also forfeit $76 million in assets.

Rapamune was originally made by Wyeth. Pfizer bought Wyeth in 2009.

The parties announced a proposed $491 million settlement in October.