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MilliporeSigma introduces excipient with sugar-like flavor

By Brian Buntz | May 31, 2022

Millipore SigmaThe Neotame Emprove Essential NF excipient from MilliporeSigma (Burlington, Massachusetts) is a high-intensity sweetener that can be used to mask the bitter flavor of active pharmaceutical ingredients.

Neotame Emprove Essential NF is a N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine-1-methyl ester.

MilliporeSigma notes that the product is a potent, synthetic sweetener with a sugar-like flavor but is between 8,000 and 13,000 times sweeter than sucrose. Neotame Emprove Essential NF offers 40 to 60 times greater sweetness potency than aspartame.

The company notes that the excipient can optimize the taste of drugs in oral solid, liquid and film dosage forms.

Neotame Emprove Essential NF is stable at room temperature and can be used in combination with other sweeteners.

Because the product has no glycemic index, it is suited for people with diabetes and phenylketonuria.

MilliporeSigma notes that the Essential NF excipient is available in 250 g and 1 kg sizes.

The company also offers sucralose, a sweetener roughly 600 times sweeter than sucrose, that is suitable for a range of pharmaceutical applications. Sucralose also offers aqueous heat and pH stability.

MlliporeSigma is a life science subsidiary of Merck KGaA, Darmstadt, Germany.

 

About The Author

Brian Buntz

The pharma and biotech editor of WTWH Media, Brian is a veteran journalist with more than 15 years of experience covering an array of life science topics, including clinical trials, drug discovery and development and medical devices. Before coming to WTWH, he served as content director focused on connected devices at Informa. In addition, Brian covered the medical device sector for 10 years at UBM. At Qmed, he overhauled the brand’s news coverage and helped to grow the site’s traffic volume dramatically. He had previously held managing editor roles on two of the company’s medical device technology publications. Connect with him on LinkedIn or email at bbuntz@wtwhmedia.com.

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