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Manufacturing Chemical Substances: Wood or Petroleum?

By Pharmaceutical Processing | October 27, 2015

Scientists create a new international research consortium to develop a sustainable chemical infrastructure.

Petroleum might well be replaced by wood soon when it comes to manufacturing chemical substances. Research has now made significant progress towards using sustainable biomass, like wood, as an alternative raw material for chemical production. Scientists at Johannes Gutenberg University Mainz (JGU) in Germany and at the University of Alabama in Tuscaloosa in the USA recently managed to synthesize two complex chemical substances from wood-based starting materials.

The process can be as cost-effective as the conventional petroleum product-based process and is less damaging to the environment.

“Our aim is to manufacture everyday products from renewable resources without an impact on the environment while at the same time ensuring that the process is economically competitive,” explained Professor Till Opatz of Mainz University. The results of their research have been published in Angewandte Chemie.

The German research team led by Professor Till Opatz at JGU’s Institute of Organic Chemistry participates in the interdisciplinary research consortium Chemical BioMedicine (ChemBioMed) funded by the Carl Zeiss Foundation and works on the synthesis of substances that can inhibit tumor cell growth.

The U.S. research group under Professor Anthony J. Arduengo III is particularly interested in developing industrially applicable methods for using materials derived from wood biomass for the sustainable manufacture of a broad array of basic chemicals such as, for example, substances used to produce automotive coatings, plastics, adhesives, and other commodity materials. 

The two teams have now been able to demonstrate wood-based, or xylochemical, syntheses of substances for which petroleum products are usually employed as starting materials. This new work shows that the relevant carbon skeletons can be created solely from wood-based starting materials. In the case of one target compound, the natural product ilicifoline B, no comparison with a petrochemical route was possible as this substance had never before been synthesized in a laboratory. But when it came to derivatives of the natural painkiller morphine, the new xylochemical synthesis turned out to be significantly more efficient than any previously known route based on petrochemistry.

An international research consortium called StanCE (Sustainable Technology for a new Chemical Economy) has been established. It brings together researchers from the USA, Germany, Japan, and Canada who are collaborating on the development of an alternative, sustainable chemical infrastructure that does not consume finite resources and avoids ecological imbalances while remaining cost-efficient.

Wood contains a variety of potential starting materials that, because of their chemical structure, are better suited than petroleum products for many applications. It is often necessary to subject the latter to extensive transformation processes before they acquire comparable functionality. 

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