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ADC Bio to Invest $11M on Bioconjugation Facility

By ADC Biotechnology | September 27, 2017

ADC Biotechnology (ADC Bio) has secured investment for the construction of an $11 million bioconjugation facility at its new site in Deeside, North Wales, UK.

The facility will cost $11 million to construct, a substantial part of which has been funded by a syndicate of technology investors, which includes Maven VCTs, Seneca and Finance Wales, and the Welsh Government, which is providing a grant.

The 6,500m2 facility—scheduled to be operational by December 2018—will support manufacturing in all clinical phases and small-scale commercial production of antibody drug conjugates. It will provide GMP production suites equipped with vessels of 10 up to a few hundred liters for batch sizes from 100 grams up to a kilo. The new integrated facility will enable ADC Bio to complement its long established technical services business that provides small scale R&D through to pre-clinical testing, with three on site laboratories and analytical testing capabilities.

The company’s move into clinical and commercial ADC manufacturing is significant as it already boasts a strong pipeline of customers. 

“We already have confirmation that many of our existing customers will use the facility for clinical development and we anticipate adding a number of the new targets entering clinical development from customers in the USA and Europe,” said Charlie Johnson, CEO of ADC Bio. 

The purpose-built, dual stream bioconjugation facility will provide a suite of capabilities ranging from R&D technical services, quality control, QA, warehousing, and process development through to manufacturing—all of which will occupy just 50% of the unit’s footprint. Consequently, ADC Bio will have free capacity to upscale quickly from early clinical phases into late phase and commercial manufacturing within the same footprint at the new facility.

Subsequent phases are planned for 2018 onwards and will add further capacity for large scale clinical and commercial, and potentially, dosage form production (fill/finish).

“We are already preparing for future phases of development and the medium-term manufacturing pipeline for the business looks extremely strong. But longer term, we also have a lot of USPs—as a standalone site with patented Lock-Release technology—which makes us extremely attractive,” added Johnson.

The company’s senior management and scientific team have decades of professional experience of developing ADCs both at ADC Bio and at rival CDMOs. Several of the company’s senior management were pivotal to the development and commercialization of Adcetris—the world’s first approved ADC. And, the company is already an integral part of the growing North West pharmaceutical manufacturing hub.

(Source: ADC Bio)

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